Sickle cell anaemia DNA Codons

Sickle-cell Anaemia 

In Sickle cell anaemia an error occurs when GAG is replaced by GTG.

GAG makes the amino acid Glutamic Acid and GTG makes the amino acid Valine.

In people with the correct amino acid GAG they are open to getting Malaria but don't have sickle-cell anaemia.

In people with the mutation amino acid GTG they are protected from Malaria but get sickle-cell anaemia. 

So it strikes me as someone in the DNA department thought he could cure Malaria victims simply by turning the cube around. Again a classic case of RNA thinking it can make adjustments and correct potential health risks but is a mere child compared to its parents DNA and doesn't always get things right.  Unfortunately the door to malaria closes and the door to sickle cell anaemia opens.

Hex - 14 6/9 GAG Glutamic Acid – SW/NE – 3/8 Crystal Air/Fire Rear - Great Possessing

Hex + 13 9/6 GTG Valine – NE/SW – 3/8 Crystal Air/Earth Face - Concording People

So this error in its entirety could be said to be contained within this one hexagram facing the wrong way. Both GAG and GTG belong to the same crystal and cube but GAG is fiery in RNA and GTG is Earthy in RNA both are tree/air element in DNA. 

Observations. As GAG is hydrophilic it would prefer to be on the outside of the DNA strand, would turning the GTG hydrophobic strand to the outside cause some of these problems. It is certainly possible to describe this problem as the shadowline because GAG and GTG belong to the same cube one facing and one rear view. One that likes moisture and one that doesn't.