Sickle Cell Mutations

In sickle cell anaemia there is an error occurring in an row of amino acids that show this way......

CTC  Leucine.......no error here
GAG Glutamic acid...... no error here

CAC  Histidine......no error here
GUG Valine ...... no error here

CTC should become GAG and CAC should become GTG which changes to GUG ...... so there is no error here.

So if the concern is that GUG is not making Glutamic Acid then that in itself would be wrong.... if you want CAC/GUG to create Glutamic Acid you should have CTC Leucine above it. So the error lies with the non coding strand above which in turn creates the error below.

On the coding strand GAG becomes GUG and this is were the error occurs in sickle cell anaemia.... so on the none coding strand CTC has changed to CAC so once again Histidine is involved. Could it be that the change from CTC Leucine to CAC Histidine could be just a half a note musically ....

CTC D# E B

CAC D# F B

From this we can observe that Leucine (E) is half a tone lower than Histidine (F) so Histidine has raised the tone by half a note which in turn matches it up to GUG Valine which because of the raise of half a tone now matches Valine and Not Glutamic Acid.

Of course it could be a coincidence...... I also believe mutations are well intended errors.... they may take years to become fixed and permanent it is not just an Crazy error in the coding department so it is meant to be for the best though one change begets another and therein lies the problem the mutated code can create. I must find more coding errors to see if raising or lowering the tone by half a note applies. Enjoy your weekend thinking. X