Sickle Cell Anaemia and DNA Codon Mutations

This is the Hexagram pairing that is involved in the mutations caused in sickle cell anaemia. In a string of proteins 147 codes long the sixth codon in the chain should be Glutamic Acid but for some reason it has been changed to Valine by the substitution of the T in GTG being made into an A producing GAG which is Glutamic acid. Lets take a look at this particular pair of Hexagrams. 

The top of the shape is GAG and the bottom of the shape is GTG.

GTG     9/6    Hex 13    NE/SW     Mars Venus    8/4 Crystal    D E A#    Alternator    Hydrophobic

                                      Valine                                                                  60 x 180 x 120 

GAG    6/9    Hex 14    SW/NE      Venus Mars    8/4 Crystal    D F A#    Lecturer       Hydrophilic

                                      Glutamic Acid                                                    90 x 150 x 120                                                                                                                     

From this pair of Hexagrams we see that GTG and GAG are closely connected and sit alongside each other in the 8/4 crystal. Just one letter changes GAG  to GTG. The nine star ki numbers are simply reversed 6/9 and 9/6. GAG takes a South West to North East direction and meets up with GTG coming the other way from North East to South West. I feel that this creates a push me pull me effect and keeps the molecule in motion. They share the planets Venus and Mars but again one is Venus and Mars and the other Mars and Venus. Musically they are the same first note D but then F and E are one whole note apart then the last musical notes are both A# so remain the same. Only that middle note changes by one whole note up or down the scale. GTG Valine 9/6 is on the right hand column of the I Ching and is usually a harmonious and balance sound but in this particular case it seems to cause many problems. It has gone from water loving to water fearing. 

GTG is an Alternator in aspect shape ...60 x 180 x 120

This shape starts in the 3rd Astrological house connected to the nervous system of Gemini an Air sign is sextile 60* to Leo in the 5th house (connected to the heart) a fire sign which is 180* to 11th house (connected to circulation) of Aquarius another air sign, in turn it creates a 120* trine aspect back to Gemini in the 3rd. So 3rd house gemini is about communications......5th house of Leo is about creativity and the 11th house of Aquarius is about liberty, freedom and your hopes and dreams. This shape is two blue lines of harmony and one red line of activity which means it lacks green energy and perhaps acts before it thinks.......maybe it can be a bit too laid back and is either working or resting in balance and harmony, switching between one and the other. 

Bodily it connects to the nervous system...the heart...circulation. 

GAG is a Lecturer in Aspect Shape... 90 x 150 x 120 

This shape starts in the 3rd astrological house of (connected to nervous system) Gemini an Air sign and is square to Virgo in the 6th house (connected to intestines) of Earth which in turn is in 150* aspect to 11th house of (connected to circulation) Aquarius another air sign.....then back to Gemini with a trine aspect. So 3rd house of communications....6th house of health and work....11th house of Liberty, Freedom and your hopes and dreams. We have a red, green and blue line in this shape which gives it all types of energy....thinking, acting and manifesting. 

Bodily it connects to the nervous system...the intestines...the circulation. 

So we are changing from Glutamic Acid GAG and its nervous system, intestines and circulation to GTG and its nervous system, heart and circulation. The focus is on the heart now not on the intestines. 

This is how the 8/4 Crystal which they both belong to appears it starts in the East AC at TGA and we see GTG in the 12th house position of hidden enemies with GAG in the 2nd house position of self esteem. The 12 codons that appear here belong to this crystal. I don’t know if they all appear in the 147 proteins associated with SCA

GTG is Hydrophobic and GAG is Hydrophilic meaning GTG likes to sit on the inner rim of a DNA Helix and GTG prefers to sit on the outside. This must mean that the very shape of the helix is being pulled in the opposite direction to its original position. 

When Valine is substituted it makes the haemoglobin molecules stick together forming long fibres that distort the shape of the red blood cells and this brings on an attack. This mutation is destructive to the red blood cells leading to oxygen being unable to bind properly and thus it curves out of shape. 

Some amino acids are hydrophobic and some are hydrophilic in some cases when a pair of Hexagrams don't match up one of them might need to become neutral so it can adapt to the situation it finds itself in, this doesn’t apply here as they are one philic and one phobic but the fact that all others will do the same must be important to the overall situation. 

The sugar phosphate backbone of DNA is hydrophilic and likes to be close to water.  The interior part of the DNA is hydrophobic and likes to stay dry on the inside.

Is it a coincidence that all Hexagram pairings match philic with phobic or one or both of them are neutral too. 

So GAG Glutamic Acid goes from being hydrophilic and water loving to being GTG Valine hydrophobic and avoiding water......perhaps the dehydration causes the folding of blood cells through being less hydrated. We also go from being on a sugar phosphate backbone of DNA which loves water and sits on the outer edge of the helix to a hydrophobic one that prefers to be on the inside staying dry. 

Bear in mind there are two versions of glutamic acid GAG as we see here and GAA but only one of them has an effect on SCA. 

There are four variations on Valine GTT GTC GTA and GTG only GTG has a connection here. I mention this to point out that even amino acids vary in one way or another from each other. 

On researching these facts I find that a contact angle of 90* or less than is classed as philic and any angle over 90* or more than is classed as Phobic. I guess when half of a shape is attracted to water and half isn’t it creates a balance its when you have too much less than or too much more than that problems can occur. As in most things in life balance rules. 

Here we see the I Ching Lines relating to these Amino Acids we see GTG which is Valine and dominates with Fire number 9 and the Glutamic Acid dominates with the number 6 Metal. The Letter A focussing on Earth energy and the letter T focussing on Fire energy. Perhaps the addition of fire to the mix creates something that is hydrophobic and drying out the codon whereas GAG is hydrophobic and does not mix well with water. Also the intestines associated with the A is replaced by the T or pumping heart along with the first G nervous system and final G Circulation.